Category: Cell biology

human cells in a blue background, 3d illustration

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News
Date
April 17, 2025

Categorized
Cell biology, Philosophy of Mind

Tagged
Cell behavior, David Coppedge, Fagunloye et al., Samejima et al., Skinner’s Constant, Waltz et al.}

How Do Individual Cells Make Decisions?

_{They have no brains but they solve problems for a purpose and make decisions. Claiming they “evolved” to do so doesn’t answer the question} _{News
April 17, 2025

9

Cell biology, Philosophy of Mind}

Material cells can only make decisions if specifically structured to follow a blueprint with rules of engagement. Where is the blueprint? Read More ›

messenger ribonucleic acid windinding around a ribosome to produce proteins

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News
Date
March 24, 2025

Categorized
Artificial Intelligence, Cell biology

Tagged
AlphaFold and IDPs, Bematist, Erik J. Larson, Hodometer, Jed Macosko}

Can AlphaFold Handle Disordered Proteins? A Biophysicist Says Yes

_{Jed Macosko takes issue with Erik J. Larson’s assessment here at Mind Matters News that proteins with no fixed order are likely to stump AI} _{News
March 24, 2025

8

Artificial Intelligence, Cell biology}

Macosko’s assessment: “AlphaFold represents a true revolution. In the end, it will be able to solve many questions about intrinsically disordered proteins.” Read More ›

3D Molecular Visualization: Complex Biomolecule Structure Models. Generative AI.

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Erik J. Larson
Date
March 19, 2025

Categorized
Artificial Intelligence, Cell biology

Tagged
AlphaFold, Dynamism in proteins, Featured, Framing problem, Intrinsically Disordered Regions (IDRs), Nuclear magnetic resonance (NMR) spectroscopy, protein folding, Protein folding and AI, Structural biology}

AI in Biology: The Future AI Didn’t Predict

_{It doesn’t look like the past. Physical systems that evolve over time but don’t follow a fixed formula have always presented a deep challenge to AI} _{Erik J. Larson
March 19, 2025

9

Artificial Intelligence, Cell biology}

The problem of outliers or “edge cases” has frustrated AI scientists and engineers (and now structural biologists) for decades, and there’s no good answer yet. Read More ›

IDP Clinical Trials: Illustrate the stages of clinical trials for drugs targeting intrinsically disordered proteins, from preclinical testing to phase III trials.

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Erik J. Larson
Date
March 14, 2025

Categorized
Artificial Intelligence, Cell biology

Tagged
AlphaFold, Alphafold2, Intrinsically Disordered Regions (IDRs)}

AI in Biology: So Is This the End of the Experiment? No.

_{But a continuing challenge is that many of the most biologically important proteins don’t adopt a single stable structure. Their functions depend on structural fluidity} _{Erik J. Larson
March 14, 2025

7

Artificial Intelligence, Cell biology}

The core issue AI isn’t just missing data — AlphaFold’s entire approach is built on assumptions that don’t apply to disordered proteins. Read More ›

AlphaFold Accuracy Visualization on a Tablet Cutting-Edge Biochemical Analysis

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Erik J. Larson
Date
March 12, 2025

Categorized
Artificial Intelligence, Cell biology, Machine Learning

Tagged
AlphaFold, DeepMind, Demis Hassabis, Intrinsically disordered proteins (IDP), John Jumper, protein folding}

AI in Biology: What Difference Did the Rise of the Machines Make?

_{AI works very well for proteins that lock into a single configuration, as many do. But intrinsically disordered ones don’t play by those rules} _{Erik J. Larson
March 12, 2025

7

Artificial Intelligence, Cell biology, Machine Learning}

The resulting problems aren’t a temporary bug — they’re a basic limitation of training a machine learning model on a dataset where proteins always fold neatly. Read More ›

the elaborate process of protein folding, essential for proper function within living organisms

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Erik J. Larson
Date
March 11, 2025

Categorized
Artificial Intelligence, Cell biology

Tagged
Artificial Unintelligence (2018), Cryo-electron microscopy, Featured, Meredith Broussard, protein folding, Protein folding and AI, X-ray crystallography}

AI in Biology: AI Meets Intrinsically Disordered Proteins

_{Protein folding — the process by which a protein arrives at its functional shape — is one of the most complex unsolved problems in biology} _{Erik J. Larson
March 11, 2025

8

Artificial Intelligence, Cell biology}

The mystery of protein folding remains unsolved because, as is so often the case with AI narratives, the reality is much more complicated than the hype. Read More ›