Tag: Intrinsically Disordered Regions (IDRs)

3D Molecular Visualization: Complex Biomolecule Structure Models. Generative AI.

^{Type
post

Erik J. Larson
Date
March 19, 2025

Categorized
Artificial Intelligence, Cell biology

Tagged
AlphaFold, Dynamism in proteins, Featured, Framing problem, Intrinsically Disordered Regions (IDRs), Nuclear magnetic resonance (NMR) spectroscopy, protein folding, Protein folding and AI, Structural biology}

AI in Biology: The Future AI Didn’t Predict

_{It doesn’t look like the past. Physical systems that evolve over time but don’t follow a fixed formula have always presented a deep challenge to AI} _{Erik J. Larson
March 19, 2025

9

Artificial Intelligence, Cell biology}

The problem of outliers or “edge cases” has frustrated AI scientists and engineers (and now structural biologists) for decades, and there’s no good answer yet. Read More ›

Dementia-related amyloid plaques and neurofibrillary tangles , neurological disorders, protein deposits

^{Type
post

Erik J. Larson
Date
March 18, 2025

Categorized
Artificial Intelligence, Medicine and Health

Tagged
AI limitations, Drug discovery, Intrinsically Disordered Regions (IDRs), Protein folding research}

AI in Biology: The Disease Connection — When Proteins Go Wrong

_{Some of the most crucial proteins for human health—the ones we need to understand most urgently—are the very ones that AI has the hardest time modeling} _{Erik J. Larson
March 18, 2025

7

Artificial Intelligence, Medicine and Health}

The issue is not simply that AI struggles with intrinsically disordered regions — it is that the very premise of IDR behavior contradicts the way these models operate. Read More ›

IDP Clinical Trials: Illustrate the stages of clinical trials for drugs targeting intrinsically disordered proteins, from preclinical testing to phase III trials.

^{Type
post

Erik J. Larson
Date
March 14, 2025

Categorized
Artificial Intelligence, Cell biology

Tagged
AlphaFold, Alphafold2, Intrinsically Disordered Regions (IDRs)}

AI in Biology: So Is This the End of the Experiment? No.

_{But a continuing challenge is that many of the most biologically important proteins don’t adopt a single stable structure. Their functions depend on structural fluidity} _{Erik J. Larson
March 14, 2025

7

Artificial Intelligence, Cell biology}

The core issue AI isn’t just missing data — AlphaFold’s entire approach is built on assumptions that don’t apply to disordered proteins. Read More ›