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TagBrain organoids

The universe inside us, the profile of a young woman and space, the effect of double exposure. scientific concept. The brain and creativity. Elements of this image furnished by NASA

Do Larger Brains Make Us Human? Is That All?

Brain organoid studies suggest a “key genetic switch” that makes human brains grow larger than ape brains

In a study of “mini-brains” (brain organoids), the size of a pea, grown in a dish and incapable of further development, researchers have discovered a “key genetic switch” that makes human brains grow three times larger than primate brains: This new research, published in the journal Cell, used brain organoids to show that this transition occurs more slowly in humans compared to gorillas and chimpanzees – over seven days, compared to five. The progenitor cells in human brain organoids not only retained their cylindrical shape for longer, but also split more frequently so more cells were produced. This was linked to a gene called ZEB2, which switches on sooner in gorilla brain organoids than in human. By delaying the effects…

Liquid Nitrogen bank containing suspension of stem cells. Cell culture for the biomedical diagnostic

Can We Make Brains in a Dish? Can We Make MINDS in a Dish?

Experiments with brain organoids have left many wondering whether we should be concerned about creating brains-in-a-dish

In a recent report, Nature addressed several studies on disembodied brains grown in the lab. One of those studies, published last year by Alysson Muotri of the University of California, San Diego, showed that brain organoids (organized clusters of brain cells) displayed electrical signals reminiscent of a twenty-five-week-old pre-term baby. the electrical activity continued for several months until the experiment was eventually stopped. Experiments with such brain organoids have left many wondering whether we should be concerned about creating brains-in-a-dish. Organoids, such as those made of kidney or liver cells, have been used to study drug development and disease. They are made either from embryonic stem cells—an ethically problematic source because they involve the destruction of an embryo—or induced pluripotent…