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TagMini-brains (brain organoids)

Organoids in petri dish .  Few distributed on growing medium. 3d illustration rendering

Lab-Grown Brains Are Closer Now. Should They Have Rights?

A new neuroscience research area raises as much concern as excitement: growing mini “human brains” in a lab. The excitement is the prospect of better understanding and treatment of dementia, autism, and motor neuron disease (ALS). The concern is that they will become sentient, capable of feeling. Then what? Starting in 2008, researchers learned that they could coax human stem cells to self-organize into “brainlike structures with electrically active neurons.” Although the cell clusters behave, to some extent, like human embryos, they are not human embryos but skin cells from an adult. That limits the ethical conflict in that the research does not depend on the abortion industry. But ethical issues crop up anyway as groups of cells become more…

The universe inside us, the profile of a young woman and space, the effect of double exposure. scientific concept. The brain and creativity. Elements of this image furnished by NASA

Do Larger Brains Make Us Human? Is That All?

Brain organoid studies suggest a “key genetic switch” that makes human brains grow larger than ape brains

In a study of “mini-brains” (brain organoids), the size of a pea, grown in a dish and incapable of further development, researchers have discovered a “key genetic switch” that makes human brains grow three times larger than primate brains: This new research, published in the journal Cell, used brain organoids to show that this transition occurs more slowly in humans compared to gorillas and chimpanzees – over seven days, compared to five. The progenitor cells in human brain organoids not only retained their cylindrical shape for longer, but also split more frequently so more cells were produced. This was linked to a gene called ZEB2, which switches on sooner in gorilla brain organoids than in human. By delaying the effects…