Mind Matters Natural and Artificial Intelligence News and Analysis

Taggain-of-function study

Young man wearing coverall and safety mask working on production line of modern pharmaceutical factory, portrait shot

U.S. Moratorium(ish) on Gain-of-Function Research

Evaluating the effectiveness of the 2014 U.S. moratorium on gain-of-function experiments

In the last two articles, we discussed the vindication of the lab leak theory through the publication of several investigative articles, and the risky nature of gain-of-function research and the evidence that it may be a key component to the cause of the COVID-19 pandemic. Now, we turn to the U.S. Due to the risky nature of gain-of-function research, what actions has the U.S. government taken to mitigate those risks? In 2014, the U.S. government placed a moratorium on new gain-of-function experiments for influenza, MERS, and SARS. That moratorium defines “gain-of-function” in very broad terms covering any “research that improves the ability of a pathogen to cause disease.” The moratorium expired in 2017 and was replaced by an oversight board,…

Medical science laboratory. Concept of virus and bacteria research

What Is Gain-of-Function Research and Why Is It Risky?

The Wuhan Institute of Virology and the NIH find themselves in a tough spot

Last time, we talked about the vindication of the lab leak theory, as a growing number of investigative articles have pointed to a lab accident as the cause of the COVID-19 pandemic. Now,we turn to the role risky gain-of-function research may have played in the affair. To understand why some in the U.S. government and the NIH want to downplay funding of gain-of-function research, we need to understand what exactly it is. All viruses mutate, some faster than others. Influenza is one of the fastest mutating viruses, followed by HIV. SARS-CoV-2 mutates slower than both viruses, which is why many scientists believe vaccine booster shots will likely be every few years, rather than annually, like the flu. Scientists need to…